Vivek Malhotra
Distinguished Professor (Visiting) School of Natural Sciences
School of Natural Sciences
In his early research, Malhotra explored the partitioning of the Golgi complex during cell division. Through a systematic search for pharmacological agents, he discovered Ilimaquinone (IQ), which induces Golgi vesiculation, mimicking the mitotic state. Investigating IQ's mechanism of action, Ma...
Research Overview
In his early research, Malhotra explored the partitioning of the Golgi complex during cell division. Through a systematic search for pharmacological agents, he discovered Ilimaquinone (IQ), which induces Golgi vesiculation, mimicking the mitotic state. Investigating IQ's mechanism of action, Malhotra uncovered a novel pathway for vesicle biogenesis, where a kinase signaling cascade activates phospholipase, leading to the generation of diacylglycerol, thus driving vesicle budding,-pioneering the concept of variable-sized vesicle formation. Recognizing the need for mechanisms accommodating large cargo in the secretory pathway, Malhotra conducted genome-wide screens, revealing the role of the TANGO1 gene family in selectively sorting and packaging bulky cargoes like collagens and chylomicrons for ER export. His exploration of TANGO's mechanism solved the longstanding challenge of accommodating cargoes larger than conventional COPII vesicles, introducing the concept of "made-to-measure" export routes. Malhotra's ingenuity extended to identifying mutations in TANGO1, directly correlating with reduced collagen secretion and resulting in significant clinical manifestations such as dwarfism and severe skeletal abnormalities. Recently, Malhotra pioneered a strategy targeting TANGO1 in hyper collagen-secreting dermal cells of scleroderma patients, offering promising avenues for alleviating skin scarring. Another TANGO gene, TANGO2, has recently been shown by Malhotra to control fatty acid metabolism. Mutations in TANGO2 lead to rhabdomyolysis, paroxysmal dystonia, and a foundation is now dedicated to addressing this devastating human pathology (https://tango2research.org). Malhotra has identified genes regulating mucin secretion quantity, linking their misexpression to ulcerative colitis. Malhotra also uncovered a new pathway where cells secrete antioxidants and cytokines independently of the conventional ER-Golgi route.
Education
Degree / Position Department / Institution Duration B.Sc Biochemistry Department, Stirling University 1978 - 1982 D.Phil Biochemistry Department, Oxford University 1982 - 1985 Postdoctoral Fellow Department of Biochemistry, Stanford University 1985 - 1990
Experience
Position Department / Institution Duration Assistant Professor Biology Department, UC San Diego 1990 - 1995 Associate Professor (Tenured) Biology Department, UCSD 1995 - 1999 Professor Cell and Developmental Biology Department, UCSD 1999 - 2008 Chair and ICREA Professor Cell Biology, CRG 2008 - Present Adjunct Professor Cell Biology Department, Yale University, USA 2019 - Present Adjunct Professor National Centre for Biological Sciences, India 2014 - Present
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Conference paper
Dynamic of Quarter Car model: Fixed Points and their Stability
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Vijayveer; Thakran, S.; Malhotra, A.; Saha, L.M. | 2025 2nd International Conference on Multidisciplinary Research and Innovations in Engineering, MRIE 2025, 70-74 | 2025 | 0 |
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Article Open access
DYNAMICS OF EVOLUTION OF A PREDATOR-PREY SYSTEM SUBJECT TO CERTAIN ENVIRONMENTAL HARVESTING
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Vijayveer; Thakran, S.; Malhotra, A.; Saha, L.M. | International Journal of Applied Mathematics, 38(3S), 191-207 | 2025 | 0 |
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Research contributions aligned with UN Sustainable Development Goals:
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Awards & Honors
- Award / Fellowship / Recognition Duration Pirie-Reid Scholar, Oxford University 1982-1985 Damon-Runyon Walter-Winchell Post-doctoral Fellow 1985-1987 American Cancer Society Senior Post-doctoral Fellow 1988-1990 Basil O'Connor Scholars Award 1992-1995 Established Investigator of the American Heart Association 1995-2000 Senior Investigator, Sandler Foundation for Asthma 2004-2007 Elected Fellow, AAAS 2005 Elected Member, EMBO 2009 ASBMB Merck Award 2013 ERC Advanced Grant 2010-2016 Miller Visiting Professor Fellowship, UC Berkeley, USA 2016 ASCB Lifetime Fellow, USA 2018 NGBT Excellence in Science Award, India 2019 Humboldt Research Award, Germany 2020 Red Bird Visiting Fellow, Institute of Advanced Studies, HKUST, Hong Kong 2023 ERC Synergy Grant 2021-2027 Elected Member, American Academy of Arts and Sciences 2024 Westlake University Distinguished Fellow (China) 2025 Vajra Distinguished Fellow (India) 2025-2027
Professional Memberships
- Committee / Role Year(s) Member, NIH Study Section - Cell Biology and Physiology-1 1995-1999 Scientific Advisory Committee, Damon Runyon Cancer Foundation 2003; 2006-2007 Review Board, CSIC Institutes, Spain 2009 EMBO Meeting Organizing Committee 2010-2011 Scientific Advisory Board, CNR, Naples, Italy 2011-2017 Scientific Advisory Board, CBMSO, Madrid, Spain 2011-2020 Scientific Advisory Board, CABIMER, Spain 2014-2023 Scientific Advisory Board, DBT, India 2015-2018 Jury, Infosys Award, India 2018 EMBO Fellowship Committee 2020-2023
Additional information will be updated soon.